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- W2366572530 abstract "AmpC β-lactamases produced by Gram-negatives is one of major drug resistant mechanisms to β-lactam antibiotics.Recently,a novel kind of AmpC β-lactamases,named extended-spectrum AmpC β-lactamases(ESAC),was reported among clinical enterobacterial isolates.They are structural varients of traditional AmpC β-lactamases by amino acid deletion,insertion and replacement.Consequently,these structural changes lead to an increased hydrolytic activity towards β-lactams.On the basis of traditional AmpC β-lactamases,an overview about the discovery,prevalence and structural-functional relationship of ESAC is provided,as well as the resistance characteristics to β-lactams of ESAC producing organisms." @default.
- W2366572530 created "2016-06-24" @default.
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- W2366572530 date "2008-01-01" @default.
- W2366572530 modified "2023-09-23" @default.
- W2366572530 title "Research Progress on the Extended-spectrum AmpC β-Lactamase" @default.
- W2366572530 hasPublicationYear "2008" @default.
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