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- W2366573584 abstract "Objective To investigate the differences of gas flow rate and volume responses(ΔFEV1 and ΔFVC,respectively,calculated by subtracting pre-bronchodilator value from the corresponding salbutamol-induced post-bronchodilator value)after routine salbutamol reversibility testing between patients with chronic obstructive pulmonary disease(COPD)and asthma.Methods Patients eligible for study were divided into COPD group(n=295)and asthma group(n=577),which were stratified according to the reduction of 0.05L in ΔFEV1,0.10L in ΔFVC,and 10 percent in FEV1 expressed as percentage of pre-bronchodilator value to its predicted value(pre-BD FEV1%pred).Then,the percentage distributions of ΔFEV1 and ΔFVC were observed,the positive rates of salbutamol test were analyzed,the differences of ΔFEV1 and ΔFVC between the two groups were compared,and the correlation of ΔFEV1 and ΔFVC was evaluated.Results The ΔFEV1 presented proximate Gaussian distribution in COPD group,but abnormal distribution in asthma group,and the distribution area was sharper in COPD group than in asthma group.The ΔFVC presented proximate Gaussian distribution in both COPD and asthma group.The positive rates in salbutamol test were lower in COPD group than in asthma group(P0.001).No significant difference was detected among the 7 subgroups of ΔFEV1 in COPD group,while significant differences were found in asthma group(P0.01).The direct correlation between total ΔFEV1 and total ΔFVC existed in both groups;however,the stratified analysis showed that there was no correlation between ΔFEV1 and ΔFVC in COPD group when pre-BD FEV1%pred ranged from 79.9 to 70.0 and from 69.9 to 60.0.Conclusion The gas flow rate and volume responses in patients with COPD differ from those with asthma after inhalation of bronchodilator,implying that different changes in pathophysiology and respiratory physiology exist in the two diseases." @default.
- W2366573584 created "2016-06-24" @default.
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- W2366573584 date "2009-01-01" @default.
- W2366573584 modified "2023-09-23" @default.
- W2366573584 title "Differences in gas flow rate and volume responses after inhalation of bronchodilator between patients with COPD and asthma" @default.
- W2366573584 hasPublicationYear "2009" @default.
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