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- W2366581322 abstract "AIM To assess the effect of Wenxinkeli on serum endothelin and myocardium cell structure of chronic congestive heart failure rats.METHODS The rat models of chronic congestive heart failure(CHF) were created by injection adriamycin(ADR) in abdomen for 6 weeks,once a week.The concentrations of ET were determined by radioimmunoassay and myocardial cell structures in different control groups were observed under electron microscope to assess the effect of Wenxinkeli.RESULTS The concentrations of ET of CHF rats were significantly increased[control group(129±26)ng/L,model group(280±25)ng/L,P0.01 as composed with control group].Wenxinkeli groups and digoxin group were apparently lower than model group[Wenxinkeli low dose group(239±35)ng/L,Wenxinkeli moderate dose group(219±32)ng/L,Wenxinkeli high dose group(191±15)ng/L,the digoxin group(187±17)ng/L,P0.01 as composed with model group].There is no significantly difference bewteen Wenxinkeli high dose group and the digoxin group.Wenxinkeli groups can improve the myocardial cell structures of the CHF rats to varying degrees.CONCLUSION It shows that the Wenxinkeli can decrease the concentrations of ET of CHF model rats and can improve the myocardial cell structures of the CHF rats.That proves that Wenxinkeli is an effective drug in treating CHF." @default.
- W2366581322 created "2016-06-24" @default.
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- W2366581322 date "2007-01-01" @default.
- W2366581322 modified "2023-09-23" @default.
- W2366581322 title "Effect of Wenxinkeli on endothelin and myocardium cell structure of congestive heart failure rats" @default.
- W2366581322 hasPublicationYear "2007" @default.
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