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- W2366585642 abstract "Objective:To investigate the correlation between p53 protein and multidrug resistance in lung cancer.Methods:The expression of p53 protein was examined by means of SP immunohistochemical technique,mdr 1 and mrp gene expression was determined by RT PCR method in 40 cases of lung cancer tissues proved by pathology and normal lung tissues of adjacent tumor.The relationship between the expression of p53 protein and mdr 1,mrp gene was analyzed respectively.Results:The positive incidence of mutant p53 was 65 %(26/40).In 26 cases of p53 positive expression,positive rates of mdr 1 and mrp gene was higher than that in p53 negative ( P 0.05).The positive expression of p53 protein and mdr 1 and mrp gene had no statistical significance in each TNM stage,pathological type,differentiated grades and with or without lymph node metastasis ( P 0.05),but their positive rates in low differentiation tumor and in patients with lymph node metastasis was higher than that of moderate to high differentiation carcinoma and in the cases without lymphatic metastasis.Conclusion:The positive correlative changes of mutant p53,mdr 1 and mrp supports the phenomenon of regulating effect of p53 on mdr 1 and mrp expression." @default.
- W2366585642 created "2016-06-24" @default.
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- W2366585642 date "2002-01-01" @default.
- W2366585642 modified "2023-09-25" @default.
- W2366585642 title "STUDY ON THE CORRELATION BETWEEN THE EXPRESSION OF p53 AND MDR IN LUNG CANCER" @default.
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