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- W2366600047 abstract "Background:Telomerase activity plays a crucial role in the immortalization of tumor cells and is tightlv regulated bv human telomerase reverse transcriptase(hTERT).Bioactive agents such as sodium butyrate and 1α,25-dihydroxyvitamin D3[l,25-(OH)_2D3]have been demonstrated to have a potential anti-tumor effect.Aims:To investigate the effect of sodium butvrate and 1.25-(OH)_2D3 on proliferation of human colon cancer cells and its potential mechanism.Methods: Human colon cancer HT29 cells were treated with sodium butyrate(0.5-2.0 mmol/L),l,25-(OH)_2D3(10~(-8)-10~(-6)mol/L)and their combination[1.0 mmol/L sodium butyrate+10~(-7)mol/L 1,25-(OH)_2D3],respectively.The growth inhibition of HT29 cells was measured by MTT assay,the cell cycle and apoptosis were assessed by flow cytometry,and hTERT mRNA expression was determined by RT-PCR.Results:Both sodium butyrate and l,25-(OH)_2D3 inhibited the growth of HT29 cells in a dose-and time-dependent manner.Sodium butyrate(1.0 mmol/L)and l,25-(OH)_2D3(10~(-7)mol/L)could arrest cell cycle in CO/G1 phase,induce apoptosis,and down-regulate hTERT mRNA expression in HT29 cells.Co-administration of sodium butyrate and 1.25-(OH)_2D3 was more effective than used alone(P0.05).Conclusions:Sodium butyrate and 1,25- (OH)_2D3 can inhibit the proliferation of human colon cancer cells.The mechanism might be related to inhibition of telomerase activity,arrest of cell cycle and induction of apoptosis by down-regulating hTERT expression.Co-administation of the two drugs has synergistic effect on human colon cancer cells." @default.
- W2366600047 created "2016-06-24" @default.
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- W2366600047 date "2011-01-01" @default.
- W2366600047 modified "2023-09-23" @default.
- W2366600047 title "Effect of Sodium Butyrate and 1,25-(OH)_2D3 on Proliferation and hTERT Expression of Human Colon Cancer Cells" @default.
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