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- W2366611043 abstract "Objective To observe the senescent changes of spleen and the anti-aging effects of traditional Chinese drug Tiannianyin on immune organs.Methods 30 SD rats were randomly divided into 3 groups and each group had 10 rats:normal,aging model and Tiannianyin groups.The sub-acutely aging model rats were made by injecting D-gal into abdominal cavity continually.After the aging model was successfully established,the rats in Tiannianyin group were administrated Tiannianyin by intragastric administration.The blood lipid and the spleen index of rats in each group were measured,and the expressions of PCNA,p53 and p16 of spleen were observed respectively.Results Compared with normal rats,the spleen index and the expression of PCNA in spleen of aging model rats decreased obviously;while the blood lipid,the expressions of p53 and p16 in spleen of aging model rats increased obviously(P0.05,P0.01).Tiannianyin could improve the senescent changes in spleen of aging rats significantly:compared with aging model rats,the spleen index and the expression of PCNA in spleen increased remarkably and the blood lipid,the expressions of p53 and p16 in spleen decreased in Tiannianyin group remarkably(P0.05,P0.01).Conclusions Tiannianyin can improve the immune function of aged by preventing atropy of spleen and facilitating the reproductive activity of lymphocytes,thus has better anti-aging effects." @default.
- W2366611043 created "2016-06-24" @default.
- W2366611043 creator A5028349844 @default.
- W2366611043 date "2009-01-01" @default.
- W2366611043 modified "2023-09-25" @default.
- W2366611043 title "The anti-aging effects of traditional Chinese drug Tiannianyin" @default.
- W2366611043 hasPublicationYear "2009" @default.
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