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- W2366618770 abstract "Objective To investigate the effects of polypyrimidine tract binding protein(PTB)on HBV posttranscriptional regulatory element(HPRE).Methods The chloramphenicol acetyl transferase(CAT)expression plasmid pDM138-HPRE system was used.Transient co-transfection was adopted to identify the roles of PTB in HPRE-regulated gene expression.Results Functional analysis indicated that PTB could inhibit HPRE function in pDM138-HPRE CAT assay system in a dose-dependent manner.PTB could also depress CAT activity when upstream splice donor site was deleted.Conclusion PTB can inhibit the function of HPRE,and this inhibition is independent on upstream splice donor site." @default.
- W2366618770 created "2016-06-24" @default.
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- W2366618770 date "2009-01-01" @default.
- W2366618770 modified "2023-09-23" @default.
- W2366618770 title "Polypyrimidine tract binding protein inhibits the function of HBV posttranscriptional regulatory element" @default.
- W2366618770 hasPublicationYear "2009" @default.
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