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- W2366639313 startingPage "e0153679" @default.
- W2366639313 abstract "The Turing instability was proposed more than six decades ago as a mechanism leading to spatial patterning, but it has yet to be exploited in a synthetic biology setting. Here we characterize the Turing instability in a specific gene circuit that can be implemented in vitro or in populations of clonal cells producing short-range activator N-Acyl homoserine lactone (AHL) and long-range inhibitor hydrogen peroxide (H2O2) gas. Slowing the production rate of the AHL-degrading enzyme, AiiA, generates stable fixed states, limit cycle oscillations and Turing patterns. Further tuning of signaling parameters determines local robustness and controls the range of unstable wavenumbers in the patterning regime. These findings provide a roadmap for optimizing spatial patterns of gene expression based on familiar quorum and gas sensitive E. coli promoters. The circuit design and predictions may be useful for (re)programming spatial dynamics in synthetic and natural gene expression systems." @default.
- W2366639313 created "2016-06-24" @default.
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- W2366639313 date "2016-05-05" @default.
- W2366639313 modified "2023-09-26" @default.
- W2366639313 title "Turing Patterning Using Gene Circuits with Gas-Induced Degradation of Quorum Sensing Molecules" @default.
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- W2366639313 doi "https://doi.org/10.1371/journal.pone.0153679" @default.
- W2366639313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4858293" @default.
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