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- W2366643521 abstract "Objective To investigate the therapeutic effects of ampelopsis grossedentataon nonalcoholic fatty liver and the possible mechanisms in mice.Methods A total of 48 male mice were randomly divided into four groups:control group,model group,positive control group,and ampelopsis grossedentata group.The model group received high fat diet.The positive control group received polyene phosphatidylcholine(150 mg/kg) for 42 days from the 14th day.The ampelopsis grossedentata group were treated with ampelopsis grossedentata(300 mg/kg) for 42 days from the 14th day.Morphological changes,liver indices,serum total cholesterol(TC),serum triglyceride(TG),alanine transaminase(ALT),aspartate transaminase(AST),liver TC,liver TG,and degrees of liver fatty degeneration were compared among the 4 groups.Results After treatment with ampelopsis grossedentata,serum levels of total cholesterol(TC),triglyceride(TG),alanine transaminase(ALT),aspartate transaminase(AST),liver TC,and liver TG were significantly decreased as compared with the nonalcoholic fatty liver model group(P0.05) and showed no significant differences when compared to the positive control group(P0.05).Histological evaluation of mice liver showed dramatically decreased lipid accumulation in the ampelopsis grossedentata group.Conclusion Ampelopsis grossedentata exhibits therapeutic effect on nonalcoholic fatty liver in mice." @default.
- W2366643521 created "2016-06-24" @default.
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- W2366643521 date "2011-01-01" @default.
- W2366643521 modified "2023-09-24" @default.
- W2366643521 title "Therapeutic Effects of Ampelopsis Grossedentata on Nonalcoholic Fatty Liver Disease in Mice" @default.
- W2366643521 hasPublicationYear "2011" @default.
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