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- W2366650187 abstract "Objective To investigate the effect of 48% chlorpyrifos on cholinesterase activity and signal transduction pathway in rats.Methods Thirty-two rats were randomly divided into low-dose(1/40 median lathal dose),moderate-dose(1/20 LD50),high-dose(1/10 LD50) groups,and saline control group.The rats were treated by oral gavage for 28 days.The activity of whole blood cholinesterase was detected with ferric chloride colorimetric method;the expression of the receptor of advanced glycation end-products(RAGE)and protein kinase C(PKC) in brain tissue were detected with the immunohistochemistry;the expression of Gq protein in brain tissue were detected with western blot.Results The activity of whole blood cholinesterase decreased with the increase of exposure,with the value of 33.75±5.03,29.70±4.01,10.40±1.95,and 5.25±0.05 for control group,low-,moderate-,and high-dose groups.The expressions of RAGE,Gq protein,and PKC increased with the increase of exposure,with the RAGE expression of 0.32±0.01,2.01±0.09,5.03±0.05,8.02±0.04,Gq protein expression of 0.84±0.01,0.90±0.01,1.10±0.02,1.59±0.01,and PKC expression of 0.12±0.01,2.01±0.03,3.52±0.02,5.01±0.08 for control group,low-,moderate-,and high-dose group,respectively.Conclusion Chlorpyrifos shows toxicity to rats by inhibiting the activity of cholinesterase.The high expression of RAGE,Gq protein and PKC might be involved nervous system pathological signal transduction in chlorpyrifos poisoning." @default.
- W2366650187 created "2016-06-24" @default.
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- W2366650187 date "2012-01-01" @default.
- W2366650187 modified "2023-09-24" @default.
- W2366650187 title "Effect of chlorpyrifos on RAGE-Gq-PKC signal transduction of brain tissue in rats" @default.
- W2366650187 hasPublicationYear "2012" @default.
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