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- W2366660926 abstract "Nabumetone was synthesized in 82% overall yield from 2-methoxynaphthalene according to the Asiam's method with some modifications.The 5-bromo substituent of 2 and C=C double bond of 4 were highly selectively removed and hydrogenated by a Pd-C/HCOONH_4 reduction system respectively.The (Ph_3P)_2 PdCl_2 formed in situ from PdCl_2 and Ph_3P catalyzed effectively the coupling of 3 with 3-buten-2-one in dimethylformamide." @default.
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- W2366660926 date "1994-01-01" @default.
- W2366660926 modified "2023-09-25" @default.
- W2366660926 title "SYNTHESIS OF NABUMETONE BY PALLADIUM CATALYZED COUPLING" @default.
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