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- W2366663752 abstract "Objective To investigate the effects of ulinastatin on the stability of lysosomal membrane and blood coagulation functions in patients undergoing mitral and aortic valves replacement. Methods Twenty consecutive patients scheduled for mitral and aortic valve replacement surgery under cardiopulmonary bypass( CPB) were randomized into two groups: ulinastatin group,who received 20 000 U / kg ulinastatin during CPB with half added into the prime solution and half added to the circuit upon aortic clamping removal; control group,who received same volume of saline. Blood sample were collected at 30 min before the operation,60 min and 120 min after the initiation of CPB,and 30 min after the termination of CPB. Serum concentration of cathepsin D( CTSD) and n- acetyl-β-glucosaminidase( NAG) were measured with ELISA. Perioperative blood coagulation functions were examined with thrombelastogram. Post operative deaths and complications,ICU stay,mechanical ventilation time,drainagevolume,urine volume and furosemide usage during the first postoperative 24 h were also recorded. Results There was no death,no severe complications in both groups. The post operative parameters such as ICU stay,mechanical ventilation time,urine volumes and furosemide usage during the first postoperative 24 h were similar between the two groups. Post operative blood coagulation functions were comparable between the two groups. Serial serum concentrations of CTSD and NAG were not significantly different between the two groups. Conclusions Compared with control,20 000 U / kg ulinastatin used during CPB has no significant effects on the lysosomal membrane stability and blood coagulation functions in patients undergoing mitral and aortic valves replacement." @default.
- W2366663752 created "2016-06-24" @default.
- W2366663752 creator A5056053058 @default.
- W2366663752 date "2013-01-01" @default.
- W2366663752 modified "2023-09-26" @default.
- W2366663752 title "Effects of ulinastatin on the stability of lysosomal membrane and blood coagulation functions in patients undergoing mitral and aortic valves replacement: a double blinded randomized controlled study" @default.
- W2366663752 hasPublicationYear "2013" @default.
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