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- W2366665822 abstract "Objective To study the curative effect and mechanism of diabetic-foot lotion on the skin ulcer of mice with diabetic foot(DF) induced by streptozotocin(STZ).Methods Ten of the fifty healthy male Kunming mice were put into the normal group and the other 40 were injected STZ 150mg/kg intraperitoneally after 12h fasting to make model,and were randomized into 4 groups,model control group,insulin group,Diabetic-foot Lotion group,and Jinhuang San control group,with 10 in each.All mice were made skin ulcer models by cutting on one side of the back to produce a skin ulcer approximately 8mm in diameter.Except for the normal control group and model control group,the other three groups were injected insulin,of them,two groups were given Diabetic-foot Lotion and Jinhuang San for exteral application.The body weight,ulcer size,and fasting blood glucose(FBG).were dynamically observed.After treatment for 30 days in succession and fasted for 8h,c-reactive protein(CRP),interleukin(IL-6),and tumor necrosis factor α(TNF-α) were determined.Results The ulcer healing of the Diabetic-foot Lotion group was earlier than that of the model control group,the difference was significant(P0.01).and the level of FBG,CRP,IL-6,and TNF-α was lower than that of the model control group,the body weight being higher than that of the model control group with significant differences(P0.05 or P0.01).Conclusion Under the premise of effective control of blood glucose with insulin,the application of Diabetic-foot Lotion quickens the ulcer healing through promoting the granulation tissue growth.Its mechanism is related to the decreases of the inflammatory cell factors." @default.
- W2366665822 created "2016-06-24" @default.
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- W2366665822 date "2011-01-01" @default.
- W2366665822 modified "2023-09-26" @default.
- W2366665822 title "Influence of Diabetic Foot Lotion on Skin Ulcer of Diabetic Foot Mice" @default.
- W2366665822 hasPublicationYear "2011" @default.
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