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- W2366701269 abstract "Objective: To observe the effect of fluvastatin on the activity of nuclear factor kappa B(NF-κB), the expressions of NF-κB mRNA and intercellular adhesion molecule -1 (ICAM-1)in the blood vessel wall of atherosclerosis (As) rabbits. Methods: Thirty-two healthy male New Zealand rabbits were divided randomly into control group, high fat diet group and fluvastatin group. They were fed for 12 weeks to build atherolerosis model and observed the formation of As plaque through aorta tissue. The activity of NF-κB and the expression of ICAM-1 were detected in immunohistochemical method and the mRNA expression of NF-κB was detected in situ hybridization. Results: The abnormality of atherosclerosis in fluvastatin group was more mitigative than that in high fat diet group (P0.01). With fluvastatin, the activity of NF-κB was cut from (40.3±5.9)% to (17.3±2.4) % (P0.01); the mRNA expression of NF-κB from (41.7±5.5)% to (19.6±1.7) % (P0.01); the expression of ICAM-1 from (31.6±2.7)% to (16.5±2.1)% (P0.01). Conclusion: The anti-atherosclerosis mechanism of fluvastatin is relevant to inhibiting the activation of NF-κB and down-regulation of the expression of ICAM-1." @default.
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- W2366701269 title "Effect of fluvastatin on the expression of NF-κB and ICAM-1 in the blood vessel wall of atherosclerosis rabbits" @default.
- W2366701269 hasPublicationYear "2005" @default.
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