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- W2366704998 abstract "Objective To study mechanisms of action of Benzo pyrene(BaP) oxidation in damage of placental villus,and to explore protective effect of Vitamin E against BaP.Methods A total of 150 viripotent ICR mice were randomly divided into five groups,females and males were raised respectively.Mice in group A were lavaged with 2 mg /(kg.d) of BaP,mice in group B,C and D were given 10 mg/(kg.d) of Vitamin E,20 mg/(kg.d) of Vitamin E and 40 mg/(kg.d) +BaP 2 mg/(kg.d) respectively,and mice in control group were lavaged with olive oil only.After 15 d of feeding males and females were raised together,the pregnant mice were continued lavaged for 7 days and then were killed.Activities of superoxide dismutase(SOD) and glutathion peroxidase(GSH-PX) in placental villus were detected.Results The activities of GSH-PX and SOD in group A,B,C and D were significantly lower than those in control group(P 0.01);activities of GSH-PX in group B,C and D were significantly higher than that in group A(P 0.05);activities of GSH-PX in group C and D were significantly higher than that in group B(P 0.01).The activities of SOD in group A,B,C and D were significantly lower than that in control group,and activities of SOD in group B,C and D were higher than that in group A(P 0.01);activity of SOD in group D was significantly lower than those in group B and C(P 0.01).Conclusion Vitamin E may inhibit the activities reduction of GSHPX and SOD induced by BaP,which may be meaningful to guide stress state and unbalance immunologic factors during gestational period." @default.
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- W2366704998 date "2013-01-01" @default.
- W2366704998 modified "2023-09-24" @default.
- W2366704998 title "Investigation of Mechanism of Action of BaP Oxidation in Damage of the Placental Villus and Protective Effect of Vitamin E" @default.
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