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• W2366705902 abstract "Objective:Investigations were performed to clarify the mechanism by which special antibodies directed against isologous lens protein antigens(ILAgs) enter the eye. Changes in the histology and physiological functions of the lens were noted.Methods:Forty-eight rabbits were selected for the study. Four of them were used to isolate Ags,twenty to create an AIC(auto immune cataract) model,and the remaining sixteen were divided into two groups. Group A served as the experimental group,while group B was the control group. The IgG from the AIC models(mainly containing antibodies directed against ILAgs) and normal animals were stained with fluorescence and then i.v. injections were administered. to the rabbits in group A and group B. Lens accommodation was measured,and slit-lamp examinations were performed before serum transfer-and 12,24,and 48 hours and 2 weeks after serum transfer. When the above procedures were completed,2 animals at a time were chosen from each group,and the eyes were removed and processed in order to observe the fluorescence phenomenon in different parts of the anterior segment.Results:In group A,12 hours post-serum transfer,the labeled antibodies first appeared in the ciliary body,lens epithelial cells,iris and corneal endothelium. Then the fluorescence enhancement reached its peak at 24 hours and was maintained until 48 hours post-serum transfer. The fluorescence disappeared 2 weeks after the procedure was performed. Under slit-lamp examination,the aqueous flare appeared at 12 hours and reached a peak 24～48 hours post-serum transfer. Half of the eyes were still aqueous flare positive 2 weeks after the procedure. There was a decrease in lens accommodation in one eye 2 weeks after serum transfer. This indicates that there was a correlation between lens damage and antibodies penetrating the lens. Aqueous flare reached a peak at the same time the antibodies penetrated the anterior chamber. Lens epithelial cell damage and reduced accommodation occurred 2 weeks post-serum transfer. No fluorescence was observed in the eyes in group B.Conclusion:In these investigations,AIC was induced by ILAgs. Then special antibodies directed against the lens could penetrate the lens through blood circulation and attack it. It can be concluded that once the special antibodies accumulated to a certain level in the anterior chamber,this triggered damage to the lens epithelium,and a cataract eventually formed. This research also indicates that special antibodies directed against the lens(IgG) could penetrate the anterior segment of eye. First they reached the ciliary bodies,then the lens epithelial cells,iris and corneal endothelium,and eventually accumulated in lens epithelial cells,subsequently followed by accumulation in the corneal endothelium. Lens accommodation was adversely affected 2 weeks following the production of special antibodies." @default.
• W2366705902 created "2016-06-24" @default.
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• W2366705902 date "2003-01-01" @default.
• W2366705902 modified "2023-09-23" @default.
• W2366705902 title "A study of labeled serum transfer in rabbits with autoimmune cataract" @default.
• W2366705902 hasPublicationYear "2003" @default.
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