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- W2366714182 abstract "Objective To investigate the value of evaluating kidney concentration ability by detecting urinary aquaporins-2 in children with pyeloureteral junction obstruction(PUJO).Methods Twelve healthy children and twenty-six hydronephrosis children with congenital unilateral PUJO were included in this study, which included fourteen mild hydronephrosis and twelve severe hydronephrosis.All were confirmed by color Doppler ultrasound and intravenous pyelogram(IVP),and the other urinary system diseases were eliminated.In the strict control condition,24h-urine was collected separately from healthy children and affected kidney of releasing ureteral obstruction in the third day,and pelvis urine of operation also was collected.The urine osmolality was measured,and AQP2 levels were measured by using enzyme-linked immunosorbent assay(ELISA).Results Comparing with the normal control,urinary AQP2 and osmolality were lower at operation(P0.05),and urine AQP2 in severe hydronephrosis were lower than those of the mild hydronephrosi(sP0.05).However,there is no significant difference between the mild and severe hydronephrosis.After releasing obstruction,there is no statistic difference in urinary AQP2 between the mild and severe group,but urine osmolality reversed.Meanwhile,urinary AQP2 and osmolality in severe group were lower than the mild group in the third day after operation(P0.05); there was a positive correlation between osmolality and AQP2 levels in normal children and those of the third day after operation.Conclusions Comparing with the normal control,urinary AQP2 and osmolality were lower than those of congenital PUJO hydronephrosis,which indicated that the decrease of AQP2 levels of urine may be related with impairment of concentrating ability of collecting duct." @default.
- W2366714182 created "2016-06-24" @default.
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- W2366714182 date "2008-01-01" @default.
- W2366714182 modified "2023-09-25" @default.
- W2366714182 title "Significance and measurement of urinary aquaporins-2 in children with congenital hydronephrosis" @default.
- W2366714182 hasPublicationYear "2008" @default.
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