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- W2366730009 abstract "Objective To investigate the efficacy of the MUC1-VNTR vaccine transfected dendritic cells (DC) in inducing specific anti-tumor immunity in CTL against the pancreatic cancer cells in vitro. Methods DCs isolated from HLA-A2 positive healthy people were transfected with the DNA vaccine MUC1-VNTR(DC-VNTR), to be cocultured with homogenous T cells to produce CTLs specific againt pancreas cancer cells. The empty plasmid (DC-pcDNA3.1) and the lipidosome-treated DC (DC-Lipo) were used as controls. The pancreatic cell lines Capan-2 and AsPC-1 were used as aim cells to check the specific cytotoxity of the CTLs. Elispot was used to check the specific CTLs that secreted IFN-γ and Gramzyme B. Results After transfection, the expression of the MUC1-VNTR was confirmed by Western blot. The CTL-mediated cytotoxity assay suggested that the T-DC-MUC1-VNTR was specific in preparing CTLs against the Capan-2 cell line and was HLA-A2 restricted. And the Elispot assay showed that the DC-VNTR could effectively induce CTLs secreting IFN-γ and Gramzyme B, while the controls could not. Conclusions The MUC1-VNTR transfected DC could induce the specific CTLs, that effectively kill the Capan-2 pancreatic cancer cell line." @default.
- W2366730009 created "2016-06-24" @default.
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- W2366730009 date "2008-01-01" @default.
- W2366730009 modified "2023-09-23" @default.
- W2366730009 title "Induction of specific anti-pancreatic cancer cell line immunity in CTLs by means of MUC1-VNTR transfected dendritic cells" @default.
- W2366730009 hasPublicationYear "2008" @default.
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