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- W2366745950 abstract "Objective To explore the role of monoaminutesergic mechanism in attention deficit hyperactivity disorder (ADHD), the serum growth hormone (GH) and prolactin (PRL) level were compared before and after a single oral administration of clonidine (an alpha adrenergic agent) to the children with ADHD Methods Thirty five children aged 7 11 years, 12 adolescents aged 12 16 years who met the DSM Ⅳ criteria for ADHD, and 10 normal controls aged 7 15 years were recruited ADHD subjects were divided into two subgroups: that with predominantly inattentive type (PI, n =21), and that with predominantly hyperactive impulsive and combined type(HI CT, n =26) based on the DSM Ⅳ subtype criteria The serum GH and PRL levels were determined by radioimmunoassay Results Clonidine provocation produced a rise of serum GH level and a decrease of PRL level in 120 minutes GH level descent in children and control group, and continue rise in adolescents group. PRL level continue decrease in adolescents and control group, and ascent in children in 180 min. No difference was found in the levels of GH and PRL before and 120 and 180 minutes after clonidine administration among ADHD children, adolescent and control group The serum GH level in HI CT subgroup rose to (12 26±6 63)μg/L at 120 minutes after clonidine administration, significantly higher than in PI subgroup [(6 16±4 59)μg/L, t =3 58, P =0 01] Conclusion The adrenergic receptor of ADHD children (specially those with hyperactive impulsive behavior)is more sensitive to clonidine excitation test than normal children Perhaps it is a biological marker for hyperactive impulsive behavior of ADHD children" @default.
- W2366745950 created "2016-06-24" @default.
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- W2366745950 date "2001-01-01" @default.
- W2366745950 modified "2023-09-23" @default.
- W2366745950 title "Neuroendocrine responses to clonidine excitation in children and adolescents with attention deficit hyperactivity disorder" @default.
- W2366745950 hasPublicationYear "2001" @default.
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