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- W2366749815 abstract "Objective To investigate the mechanism and clinical reliability of applying 188 Re radioactive nanometre particle esophageal stent. Methods An elastic meshed esophageal stent made of double membranous nickel titanium alloy and loaded with 188 Re radioactive nanometre particles was used . The stent was introduced into the esophagus of eight experimental pigs and fixed in place.Two pigs served as controls.With the pig aneasthetized, the stent with good expandability was placed in the proper position.Radioactive ?MBq was applied to the 8 experiment pigs while the two control pigs received only the stent without the radioactive material.Three hours after the insertion of the stent,the pigs were allowed to feed,without any choking observed. Results Seven days after the treatment of pathologic experiment pigs showed infla?mmatory celluar infilfration,congestion and edema in the mucosa and submucous layer.After 21 days,some parts of the esophageal mucosa showed thickening of the vascular layer of the blood vessels and scanty fibrous hyperplasia.Seven days after application of larger dose of 259?MBq stent,pathology examination carried out in the experiment pigs showed extensive infla?mmatory cellular infilfration,edema and congestion in the muscles and submucosa, and patch like necrosis.Twenty one days after application,repairing fibrous hyperplasia appeared.In the control pigs,not even any traumatic damage was observed.Periodic checking of the stool did not show any leakage of radioactivity and there was no displacement of the stents as confirmed by X ray exam.Conclusions The stent is effective to maintain an unobstructed passage of food . The loaded radioactive particles can be concentrated in the target area and adjusted by a body surface magnetic modulation and inhibit the intraluminal epithelial growth of esophageal mucosa without any severe radiation reaction or damage. It is quite promising to resolve the obstruction of advanced esophageal cancer with radioactive self expandable metallic stent." @default.
- W2366749815 created "2016-06-24" @default.
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- W2366749815 date "2004-01-01" @default.
- W2366749815 modified "2023-09-25" @default.
- W2366749815 title "Animal experiment on ~(188)Re-radioactive nanometre particle esophageal stent" @default.
- W2366749815 hasPublicationYear "2004" @default.
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