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- W2366752007 abstract "Objective:To study the relationship between the expression of signal transducer and activator of transcription 3 (STAT3) and vascular endothelial growth factor (VEGF) in salivary gland tumor and the degree of malignant,as well as their significance. Method:The expression of STAT3 and VEGF in 49 cases of salivary gland tumor and 16 cases of normal salivary gland tissues were detected by immunohistochemical assay. Result:The positive rates of expression of STAT3 and VEGF were significantly higher (p0.05) in the malignant salivary gland tumor group than that in the benign salivary gland tumor group,while the benign salivary gland group was significantly higher (p0.05) than that in normal salivary tissue. The expression of STAT3 was positively correlated to the expression of VEGF (p0.05) in the salivary gland tumor. Conclusion: The expression of STAT3 and VEGF are closely related to the degree of salivary gland tumor malignance,and they play an important role in the pathogenesis and development of salivary gland tumor. It conform to the paint of view that VEGF gene is regulated directly by STAT3 protein. The inhibition of STAT3 pathway may become a new way to treat salivary gland tumor." @default.
- W2366752007 created "2016-06-24" @default.
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- W2366752007 date "2009-01-01" @default.
- W2366752007 modified "2023-09-26" @default.
- W2366752007 title "Expression of STAT3 and VEGF in salivary gland tumor and their clinical implication." @default.
- W2366752007 hasPublicationYear "2009" @default.
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