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- W2366766512 abstract "The effect of Rhizoma Paridis s ap onins (RPS)on acute analgesia tolerance to morphine in complete Freund's adj uvant induced arthritic(AIA)rats in warm water tail flick test was observed, th e changes of β endorphin (β EP) and adrenocorticotropic hormone (ACTH) level in the brain of rats were also assayed with radioimmunoassay methods. The rat m odels of acute analgesia tolerance to morphine were established when the AIA rat s received an intermittent injection of morphine every 2 h , the ACTH and β E P levels in the hippocampus , β EP level in the hypothalamus were found sign ificantly decreased. When the rats had orally taken RPS (60 mg/kg), the pain beh avior scores were decreased markedly and the warm water tail flick latency was increased significantly. Meanwhile, the ACTH levels in the hippocampus and hypot halamus,β EP level in the hypothalamus were increased significantly. The corre lation between the effect of RPS on the level of ACTH in the hypothalamus and th e pain behavior scores of morphine tolerance in AIA rats were significant at 0.0 1 level. The results suggest that RPS attenuate the development of acute analges ia tolerance to morphine in AIA rats by reversing the decline of ACTH level in t he hypothalamus ." @default.
- W2366766512 created "2016-06-24" @default.
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- W2366766512 date "2001-01-01" @default.
- W2366766512 modified "2023-09-25" @default.
- W2366766512 title "Rhizoma Paridis saponins reverses the decline of ACTH in hypothalamus of mo rphine tolerant arthritic rats" @default.
- W2366766512 hasPublicationYear "2001" @default.
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