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- W2366768984 abstract "Background and purpose:It was reported that chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1(SDF-1)were involved in the proliferation,differentiation,and metastasis of tumor.This study was designed to observe the expression of chemokine receptor CXCR4 in hypopharyngeal squamous cell carcinoma tissue and study the relationship between the expression of chemokine receptor CXCR4 and different clinicopathlogical characteristics,and further to explore the clinical significance.Methods:For the detection of the expression of chemokine receptor CXCR4,43 primary hypopharyngeal squamous cell carcinoma tissues,27 normal hypopharyngeal tissues,34 lymph node metastastatic lesions and 9 normal lymph node lesions were detected by immunohistochemical method using rabbit anti-human CXCR4 polyclonal antibody.Results:The positive expression rates of CXCR4 in 43 hypopharyngeal carcinoma tissues and normal tissues were 95.3% and 22.2%,respectively(P0.01).The positive expression rate of CXCR4 in lymph node metastasis lesion was 82.4%,which was significantly higher than that of negative lymph node(P0.01).The positive expression rate of CXCR4 in hypopharyngeal carcinoma rose with the decrease of the differentiation grade of hypopharyngeal carcinoma(P0.05).There was a significant association between the expression of CXCR4 and T stages(P0.01),regional lymph node metastases(P0.01),and differentiation grade(P0.05).Conclusions:Chemokine receptor CXCR4 was highly expressed in hypopharyngeal carcinoma,and their expression was significantly correlated with clinical stage of hypopharyngeal carcinoma,differentiation grade and regional lymph node metastasis.CXCR4 might be a valuable biomarker to predict the progression of hypopharyngeal carcinoma." @default.
- W2366768984 created "2016-06-24" @default.
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- W2366768984 date "2008-01-01" @default.
- W2366768984 modified "2023-09-26" @default.
- W2366768984 title "Expression of chemokine receptor CXCR4 in hypopharyngeal carcinoma and its significance" @default.
- W2366768984 hasPublicationYear "2008" @default.
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