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- W2366769602 abstract "Objective To study the expression of β 3 adrenoceptor (β 3 AR) and its function in human detrusor cells. Methods Cellular functional studies,radioligand binding experiments and reverse transcription polymerase chain reaction were used to determine the expression and its influence on detrusor contractions. Results mRNA of 3 subtypes of β ARs was detected. Non selective β AR agonists and β 3 AR decreased the contractions of detrusor cells induced by KCL, but both agonist and antagonists of β 1 and β 2 AR could not influence the contraction;BRL37344 concentration dependently displaced dihydroalprenolol binding to the membrane of detrusor cells. Conclusions The mRNA of subtypes of β ARs is distributed in human detrusor cells,but β 3 ARs is the main receptor mediating detrusor relaxation." @default.
- W2366769602 created "2016-06-24" @default.
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- W2366769602 date "2002-01-01" @default.
- W2366769602 modified "2023-09-25" @default.
- W2366769602 title "Expression of β_3 -adrenoceptor and its function in human detrusor cells" @default.
- W2366769602 hasPublicationYear "2002" @default.
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