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- W2366798759 abstract "Objective To investigate the clinical features and treatment of the patients with anti-N-methyl-D-aspartate receptor( NMDAR) encephalitis. Methods We summarized the clinical data of two cases which with confirmed diagnosis of anti N-methyl-D-aspartate receptor encephalitis,and related literature was reviewed. These literature was published in various journals of China from 2010 to 2013 and was gotten through computer retrieval CNKI,Wan Fang database. Results These two reported and other twenty-three retrieved cases mainly manifested as fever,mental and behavior abnormalities,mental retardation,convulsions,involuntary movement and autonomic nerve dysfunction performanced for sleeplessness,quick heart rate,abnormal secretion of sweat. Of the two patients were not associated with teratoma,one was male,15. 5years old,and the other one was female,14 years old. The other twenty-three cases were retrievaled through literature including 14 female and 9male. There were five patients with teratoma in these twenty-three cases. All cases were confirmed by blood tests and / or cerebrospinal fluid anti NMDA receptor antibody. White blood cells which manifested as lymphocyte count mildly elevated in cerebrospinal fluid. Head MRI examination and EEG found no specific appearance. Blood anti streptolysin O increased in these two cases. These two reported and other twenty retrieved cases treated with large dose of hormone and immunoglobulin were effective. The effect was not obvious in two cases and one case died. Conclusion Anti N-methyl-D-aspartate receptor encephalitis has no specific clinical manifestations. It is easy to be misdiagnosed as mental disorder in early stage. Detection of anti NMDA receptor antibody in cerebrospinal fluid is helpful to early diagnosis and treatment,and then immunotherapy is effective. These two cases reported in this paper were combined with the increase of ASO,which has not been reported before in the literature." @default.
- W2366798759 created "2016-06-24" @default.
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- W2366798759 date "2015-01-01" @default.
- W2366798759 modified "2023-09-23" @default.
- W2366798759 title "A report of 2 cases and review of literature about anti-N-methyl-D-aspartate receptor encephalitis" @default.
- W2366798759 hasPublicationYear "2015" @default.
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