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- W2366799709 abstract "AIM To determine L-carnitine levels in human plasma by LC-MS/MS and to study the bioequivalence and pharmacokinetics of reference and test L-carnitine formulations.METHODS A double-phased stochastical crossover study was designed.Eighteen healthy volunteers were given a single dose of 2 g L-carnitne of reference and test formulations individually.The drug in plasma was detected by LC-MS/MS.DAS 2.0 software was utilized to determine the pharmacokinetic parameters and relative bioavailability.RESULTS The main pharmacokinetic parameters t12,ρmax,tmax,AUC0→24 h and AUC0→∞of reference and test L-carnitine formulations were(24.2±8.9) and(22.8±11.0) h,(15.8±3.8) and(14.9±3.8)μg·mL-1,(4.8±0.7) and(4.4±1.1)h,(253.0±56.9) and(246.2±57.8)μg·h·mL-1,(511.2±154.3) and (512.9±218.0)μg·h·mL-1,respectively.The relative bioavailability of test chewable tablet was(97.9±12.4)%(91.9%-102.6%).CONCLUSION The method is simple, accurate and sensitive,and two formulations are bioequivalent." @default.
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- W2366799709 date "2009-01-01" @default.
- W2366799709 modified "2023-09-25" @default.
- W2366799709 title "Bioequivalence and pharmacokinetics of L-carnitine chewable tablets in healthy volunteers" @default.
- W2366799709 hasPublicationYear "2009" @default.
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