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- W2366800570 abstract "Objective:To establish a HPLC method for the determination of concentration of ambroxol hydrochloride in human plasma.Methods:Ambroxol hydrochloride in human plasma(with nicardipine hydrochloride as internal standard)was detected at 245nm after liquid-liquid extraction.The separation was performed on a C18 reversed-phase column with a mobile phase of methanol-acetonitrile-0.01mol·L-1 phosphate buffer(45∶27∶28).Results:The calibration curve of ambroxol hydrochloride was obtained in the range of 10~480ng·mL-1 with good linearity(r=0.9999).The recoveries of methodology were more than 94%.The inter-day and intra-day RSD were less then 5%.Conclusion:This method has good sensitivity and precision and is suitable for pharmacokinetic studies of ambroxol hydrochloride in humans." @default.
- W2366800570 created "2016-06-24" @default.
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- W2366800570 date "2008-01-01" @default.
- W2366800570 modified "2023-09-23" @default.
- W2366800570 title "Determination of ambroxol hydrochloride concentrations in plasma by HPLC and its application to pharmacokinetic studies" @default.
- W2366800570 hasPublicationYear "2008" @default.
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