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- W2366803913 abstract "AIM: To examine the effects of angiotensin Ⅱ (AngⅡ) on intracellular free calcium concentration ([Ca 2+ ] i) in human atrial myocytes and the antagonism effect of telmisartan. METHODS: Single human atrial myocyte was isolated. Four groups were included in the experiment: control group, AngⅡ group, telmisartan group, and AngⅡ + telmisartan group. Confocal microscope was used with Fluo-3/AM as calcium indicator to detect the changes of [Ca 2+ ] i immediately and 15 minutes respectively after the drug intervention. RESULTS: The intracellular fluoresence intensity of singular cardiomyocytes in control and telmisartan groups was low and the intracellular fluoresence intensity of singular cardiomyocytes in AngⅡ group was significantly higher than that in the control group 15 minutes after intervention (P0.01). When telmisartan was added simultaneously with AngⅡ intervention, the values were much lower compared with those in AngⅡ group (P 0.01) . CONCLUSION: AngⅡ induces intracellular calcium overload in human atrial myocytes and telmisartan can decrease [Ca 2+ ] i overload in human atrial myocytes induced by AngⅡ." @default.
- W2366803913 created "2016-06-24" @default.
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- W2366803913 date "2005-01-01" @default.
- W2366803913 modified "2023-09-24" @default.
- W2366803913 title "Effects of angiotensin II on intracellular free calcium concentration in human atrial myocytes and antagonistic effect of telmisartan" @default.
- W2366803913 hasPublicationYear "2005" @default.
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