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- W2366821654 abstract "Aim To investigate effects of loureirin B on capsaicin-evoked currents in rat dorsal root ganglion (DRG) neurons. Methods In acutely isolated rat DRG neurons, effects of loureirin B on capsaicin-evoked currents were observed using whole-cell patch-clamp technique. Results ① The holding potential was maintained at -60 mV and VR1 antagonist capsazepine inhibited capsaicin-evoked currents completely; ② Loureirin B concentration-dependently inhibited capsaicin-evoked currents. Loureirin B at the concentrations of 2.0, 4.0, 8.0 and 16.0 μmol·L-1 reduced capsaicin-evoked currents by 15.36%±2.12%、36.41%±2.43%、76.26%±2.16% and 96.69%±3.21% (n=10, P0.05) of the control respectively with half-maximal inhibitory concentration (IC50) of 4.9 μmol·L-1, Hill coefficient of 2.29. Conclusion Loureirin B could markedly inhibit capsaicin-evoked currents and block the transmission of pain sensation, which may contribute to one of analgesic mechanisms of dragon′s blood (its important component is loureirin B)." @default.
- W2366821654 created "2016-06-24" @default.
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- W2366821654 date "2007-01-01" @default.
- W2366821654 modified "2023-09-28" @default.
- W2366821654 title "Loureirin B inhibits capsaicin-induced currents in rat dorsal root ganglion neurons" @default.
- W2366821654 hasPublicationYear "2007" @default.
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