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- W2366830557 abstract "AIM To investigate the protective effects of allopurinol sustained-release capsules(ASRC) on kidney in hyperuricacidemia rats by long term administration.METHODS Ninety Wistar rats were randomized into control group(n= 10),model group(n = 16),ASRC groups(27,54 mg·kg~(-1)·d~(-1),n = 16 each group),and allopurinol tablet groups(32,64 mg·kg~(-1)·d~(-1),n = 16 each group).Hyperuricemia model was induced by introgastric administration to rats with adenine and ethambutol for 12 weeks.Drug administration was started at the same time.Serum uric acid concentration was measured,the functional and pathological changes in kidney were observed,and the expression of TNF-αin kidney was evaluated.RESULTS Compared with control group,the concentration of serum uric acid(UA) and blood urea nitrogen(BUN),the expression of TNF-αin kidney,and the water content of renal tissue increased significantly in the model group(P0.05). Compared with the model group,the concentration of serum UA and BUN,and the expression of TNF-αin kidney decreased significantly in high-dose ASRC group(P0.05),the water content of renal tissue decreased significantly in low-dose ASRC group(P0.05).There were no significant differences in serum creatinine levels and kidney index(P0.05).Compared with high-dose allopurinol tablet group,the kidney index and water content of renal tissue decreased significantly in ASRC groups(P0.05,P0.01).CONCLUSION Long-term administration of ASRC has protective effects for kidney in hyperuricacidemia rats,which might be related to reducing serum uric acid levels and restraining the inflammatory response induced by TNF-α." @default.
- W2366830557 created "2016-06-24" @default.
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- W2366830557 date "2012-01-01" @default.
- W2366830557 modified "2023-09-23" @default.
- W2366830557 title "Effects of allopurinol sustained-release capsules on kidney in hyperuricacidemia rats by long term administration" @default.
- W2366830557 hasPublicationYear "2012" @default.
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