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- W2366838848 abstract "Objective :To develop a LC-MS/MS method for the determination of tanshinone I,cryptotanshinone and tanshinone IIA in rat plasma and to investigate the pharmacokinetics of the three tanshinones.Methods :The plasma samples were protein precipitated with methanol.After sample preparation,the samples were separated on an Agilent Zorbax SB-C18(2.1 mm×150 mm,5 μm)column using methanol(containing of 0.1% formic acid)and water(containing of 0.1% formic acid)as mobile phase in gradient elution mode.The mass spectrometer was operated under the positive ion mode with the ESI source and the detection was performed by selected reaction monitoring(SRM)of the transition of m/z 277.1→249.1 for tanshinone I,m/z 297.1→251.2 for cryptotanshinone,m/z 295.1→277.1 for tanshinone IIA and m/z 360.9→233.0 for fenofibrate.Results :The calibration curves for tanshinone Ⅰ,cryptotanshinone and tanshinone IIA were all linear over the range of 2-100 ng.mL-1.The intra-day and inter-day precisions were within 12.0% and the average recovery was above 89.4%.Conclusion :The analysis method is sensitive,simple and suitable enough to be applied in the pharmacokinetic study of tanshinone Ⅰ,cryptotanshinone and tanshinone IIA." @default.
- W2366838848 created "2016-06-24" @default.
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- W2366838848 date "2013-01-01" @default.
- W2366838848 modified "2023-09-25" @default.
- W2366838848 title "Simultaneous Determination of Three Kinds of Tanshinone in Rat Plasma and Pharmacokinetics by LC-MS/MS" @default.
- W2366838848 hasPublicationYear "2013" @default.
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