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- W2366846114 abstract "Objective:To investigate the effects of Yixinnao dripping pills on platelet aggregation and thrombus formation in rats,as well as the effects on coagulability activity.Method: The Wistar rats were divided into normal control group,aspirin group,Yixinnao dripping pills high,middle and low dose group(906,453,226 mg · kg-1,ig,accordingly).The effects of Yixinnao dripping pills on platelet aggregation in vivo were measured by the model induced by ADP,thrombin and CaCl2.Coagulation time in acute blood stasis rat models was determined by the glass capillary method and the effects were also evaluated on prothrombin time(PT) and thrombin time(TT) in these groups.The inhibitory action of Yixinnao dripping pills on the thrombus formation was investigated by the model of artery-vein bypass thrombosis.Result: Yixinnao dripping pills in the high,middle and low dose could signifiinhibit platelet aggregation induced by ADP,thrombin and CaCl2,respectly(P0.05 or P0.01).It could also lengthen coagulation time,TT and PT in different degree(P0.05 or P0.01).Moreover,Yixinnao dripping pills(906,453 mg · kg-1) could markedly restrain thrombus formation,reduce thrombus weight(P0.05 or P0.01).Conclusion: Yixinnao dripping pills showed the function of anti-thrombosis,and exerted the effects on inhibition of platelet aggregation and coagulability." @default.
- W2366846114 created "2016-06-24" @default.
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- W2366846114 date "2013-01-01" @default.
- W2366846114 modified "2023-09-23" @default.
- W2366846114 title "Effects of Yixinnao Dripping Pills on Platelet Aggregation and Thrombus Formation and Coagulability Activity" @default.
- W2366846114 hasPublicationYear "2013" @default.
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