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- W2366865046 abstract "OBJECTIVE:To determine the reversal effect of N-acetylcysteine on cisplatin resistance of the A549/DDP cell line of human lung adenocarcinoma,and discuss the relation ship between N-acetylcysteine and multidrug resistance protein-1.METHODS:The cytotoxic effect of different concentrations of N-acetylcysteine and the sensitivity of cisplatin were determined by the MTT assay.RT-PCR was applied to detect the MRP mRNA before and after A549/DDP was treated with N-acetylcysteine.RESULTS:The groups with the concentrations of 10,20 and 50 μg/L of NAC increased the sensitivity of cisplatin in A549/DDP,and the groups of the concentrations 0.1 and 1 μg/L of NAC did not increase the sensitivity obviously.MRP1 transcripts decreased after treated with 10,20 and 50 μg/L of NAC.CONCLUSIONS:NAC can reverse the sensitivity of cisplatin of A549/DDP,which suggests that it is not to have the microenvironment to induce the NAC to GSH.NAC can decrease the MRP1 transcript to reverse the sensitivity of cisplatin." @default.
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- W2366865046 date "2009-01-01" @default.
- W2366865046 modified "2023-09-26" @default.
- W2366865046 title "Reversal effect of N-acetylcysteine on cisplatin resistance of A549/DDP cell line of human lung adenocarcinoma and relation ship between N-acetylcysteine and multidrug resistance protein-1" @default.
- W2366865046 hasPublicationYear "2009" @default.
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