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- W2366866421 abstract "Objective To establish an animal model for Alzheimer′s disease (AD) and to observe the neurotoxic effects of β amyloid (Aβ) in vivo Methods The rats were divided into four groups The model group was administered Aβ 1 40 into bilateral CA 1 subregion in hippocampus The control group was administered saline in the same way Sham operation group and normal group were set up as additional control All the rats in various groups were tested with Y maze two weeks after injection HE, Congo Red staining, Nissle staining, and the histochemical method for acetylcholinesterase (AChE) were used to detect the histological changes in hippocampus The data were analyzed with One Way Analysis of Variance and T Test Results The model rats showed lesser AChE positive fibers density in hippocampus and worse ability in learning and memory compared with those of control rats The length of lesion in CA 1 pyramidal cell layer was (1 94±0 23) mm after Aβ 1 40 injection and (0 35±0 07) mm after saline injection, which was significantly different (P0 01) between the model group and control group Conclusions Rats injected with Aβ 1 40 into hippocampus may be a kind of useful AD model, especially in the study of neurotoxic effects of Aβ and treatment of AD" @default.
- W2366866421 created "2016-06-24" @default.
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- W2366866421 date "2000-01-01" @default.
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- W2366866421 title "Study of rats with β-amyloid injection into hippocampus" @default.
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