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- W2366871246 abstract "Objective To study the features of hippocampal atrophy (HA) by MRI in mild Alzheimer's disease(AD) patients. Methods Fifteen mild AD patients and 30 healthy controls were included in this study and all subjects were examined by both MRI and MMSE. The differences in the hippocampal volume between the mild AD and the control were analysed, and relationships between the hippocampal volume and age, MMSE scores were evaluated. Results The hippocampal volume of the mild AD was decreased significantly than that of the controls 〔(2 08±0 46)cm 3 vs (3 11±0 19)cm 3, t =2 71, P 0 01)〕. The volume of 13 3% of the mild AD patients was within the range of the control group and the mean volume of AD patients was reduced 4 42 s compared to the controls. The hippocampal volume in both AD and control group reduced with aging, and being significantly faster in AD patients than in the healthy controls( t =2 07, P 0 05). There was a positive relationship between the hippocampal volume and MMSE score in the mild AD ( r = +0 48, P 0 05), and no relationship was found in the controls( r =0 19, P 0 05). Conclusions MRI-based HA could be used to differentiate the mild AD patients effectively from the healthy subjects and could also be regarded as a status marker for the early clinical diagnosis of AD." @default.
- W2366871246 created "2016-06-24" @default.
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- W2366871246 date "2001-01-01" @default.
- W2366871246 modified "2023-09-27" @default.
- W2366871246 title "MRI study on the hippocampal atrophy due to mild Alzheimer's disease" @default.
- W2366871246 hasPublicationYear "2001" @default.
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