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- W2366884928 abstract "OBJECTIVE To investigate the mechanism of apoptosis of retinal ganglion cell (RGC) on the diabetic rats and it was inhibited by traditional Chinese medicine for ushenhuoxue(补肾活血)therapy.METHODS The animal model of diabetes mellitus was introduced by streptozotocin, then gave suspension of the traditional Chinese medicine for bushenhuoxue therapy and phenformin for six months. The number of RGC and the content of the Nissl body and B cell lymphoma, leukemia 2 (bcl-2), and Bcl-2 associated X protein (bax) and Neurotrophin-3 (NT-3) protein were measured semi-quantitatively with toluidine blue-eosin staining and immunohistochemistry methods combined with image analysis system. Ratio of bcl-2/bax protein was counted, then linear multianalysis regression was used for stepwise method. RESULTS Compared with normal group, the number of RGC reduced obviously in the model group(P0.001), and the content of the Nissl body and the bcl-2 and NT-3 and bcl-2/bax protein decreased notably (P0.001), and the content of the bax protein increased notably in the model group(P0.001).Compared with model group, the number of RGC increased obviously (P0.001), and the content of the Nissl body and the bcl-2 and NT-3 and bcl-2/bax protein increased notably (P0.001), and the content of the bax protein decreased notably in the bushenhuoxue group (P0.001). The result of regression analysis showed that the number of RGC and the content of the Nissl body was a positive relation to ratio of bcl-2/bax protein, the former :r=0.754,P0.001; and the latter r=0.578 P0.001. CONCLUSION The mechanism of apoptosis of retinal ganglion cell in diabetic rats and that was inhibited by traditional Chinese medicine for bushenhuoxue therapy was mainly of adjusting ratio of bcl-2/bax protein, then changes of content of neurotrophic factor NT-3 bringed partial effects into play." @default.
- W2366884928 created "2016-06-24" @default.
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- W2366884928 date "2003-01-01" @default.
- W2366884928 modified "2023-09-25" @default.
- W2366884928 title "The mechanism of apoptosis and effect on inhibition in retinal ganglion cells of rats with diabetes mellitus and its inhibition by traditional Chinese medicine for bushenhuoxue(补肾活血)therapy" @default.
- W2366884928 hasPublicationYear "2003" @default.
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