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- W2366885769 abstract "Objective:To investigate the effect of paclitaxel and TNF-α on prostatic carcinoma,and explore its mechanism.Methods:To establish a subcutaneous prostatic carcinoma implant model on nude mice and observe the combined inhibitive effect of paclitaxel and TNF-α on the tumor model.Reverse transcript polymerase chain reaction and immunohistochemistry were employed to observe Bax,Bcl-2 and p53 gene expression.Results:Comparing with paclitaxel treated group,TNF-α treated group and the control group,combined treatment of paclitaxel and TNF-α could inhibit subcutaneous prostatic carcinoma implant growth.The tumor volume obviously decreased.RT-PCR showed that Bax expression was obviously up-regulated,while Bcl-2 expression was obviously down-regulated.Immunohistochemistry showed that p53 expression was down-regulated.Conclusion:The combined treatment of paclitaxel and TNF-α may exert an inhibitive effect on prostatic carcinoma by up-regulating Bax expression,which could further induce accelerated apoptosis." @default.
- W2366885769 created "2016-06-24" @default.
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- W2366885769 date "2008-01-01" @default.
- W2366885769 modified "2023-09-23" @default.
- W2366885769 title "Combined inhibitive effect of docetaxel and TNF-α on subcutaneous prostatic carcinoma implant" @default.
- W2366885769 hasPublicationYear "2008" @default.
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