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- W2366885882 abstract "Objective:To explore changes of large arterial structure and function in salt sensitive hypertensive rats.Methods:A total of 23 12-week-old SD rats were randomly divided into sham operation group(n=10) and hypertension induced by deoxycorticosterone acetate(DOCA) salt group(n=13).Changes of their peripheral and central arterial pressure,pulse wave velocity(PWV),intima-media thickness(IMT) of carotid and thoracic aorta was observed.Changes of components of collagen/elastin on vessel wall were analyzed.Results:Compared with sham operation group,peripheral systolic blood pressure significantly increased,and there were also significant increase in central SBP(cSBP),central diastolic blood pressure(cDBP),central mean blood pressure(cMBP),P0.01 all,and PWV of thoracic aorta [(4.81±0.14) m/s vs.(6.33±0.20) m/s,P0.01] also significantly increased in DOCA rats at the end of modeling.Carotid IMT [(46.00±4.00)μm vs.(78.00±4.90)μm] and aortic media thickness(MT) [(120.48±7.93)μm vs.(194.25±5.66) μm] significantly thickened(P0.01 both),and collagen concentration on vessel wall [(0.87±0.05)mg/cm vs.(1.00±0.03)mg/cm,P0.05] also significantly increased in DOCA rats.Conclusion:The blood pressure and artery stiffness in DOCA-salt-hypertensive rats significantly increase;change of arterial stiffness is related with thicken of large arterial wall and change of collagen concentration besides impact from blood pressure." @default.
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- W2366885882 date "2011-01-01" @default.
- W2366885882 modified "2023-09-25" @default.
- W2366885882 title "Changes of arterial structure and function in hypertensive rats induced by deoxycorticosterone acetate salt" @default.
- W2366885882 hasPublicationYear "2011" @default.
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