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- W2366887373 abstract "OBJECTIVE: To compare the bioequivalence of 2 kinds of Azihromycin tablets in healthy volunteers. METHODS: 2 kinds of Azihromycin tablets were administered by randomized crossover way in 18 male volunteers for 2 periods, and the blood concentrations of azihromycin were determined by microbiological assay. The pharmacokinetic parameters were calculated with 3p97 pharmacokinetic program and the bioequivalence was evaluated. RESULTS: Main pharmacokinetic parameters were as follows: cmax(1.21±0.56)μg·mL-1 and (1.25±0.62)μg·mL-1; tmax(1.94±0.64)h and (2.44±1.15)h; AUC0～144 h(11.33±7.49)μg·h·mL-1 and (11.61±7.15)μg·h·mL-1. The relative bioavailability of test tablets was (97.59±12.72)%. CONCLUSION: Results of variance analysis and t-tests suggest that 2 kinds of Azihromycin tablets are bioequivalent." @default.
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- W2366887373 date "2012-01-01" @default.
- W2366887373 modified "2023-09-24" @default.
- W2366887373 title "Bioequivalence of 2 Kinds of Azihromycin Tablets in Healthy Volunteers" @default.
- W2366887373 hasPublicationYear "2012" @default.
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