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- W2366888917 abstract "Objective:To establish an HPLC method for the determination of itraconazole and its metabolite hydrox- yitraconazole in human plasma. Methods:Dikma Diamonsil C18 HPLC column (200 mm×4.6 mm,5μm) was used; Column temperature was 40℃; The mobile phase consisted of 0.1% triethylamine buffer(adjusted pH to 2. 5 with 85% phosphoric acid) -acetonitrile(30:70); The flow rate was 1.2 mL·min-1;The detector was fluorescence detector, excitation wavelength and emission wavelength was set at 260 nm and 365 nm respectively. R051012 was used as the internal standard,the plasma samples were extracted by methyl tert - butyl ether. Results: The linear range of itraconazole and its metabolite hydroxyitraconazole were all 5 - 500 ng·mL-1. The extraction recovery of itraconazole and its metabolite hydroxyitraconazole were more than 80% ; Intra-day RSD and inter-day RSD were less than 10%. Conclusion:This method is proved to be sensitive,fast and accurate. Therefore,it can be used for therapeutic drug monitor and pharmacokinetic study." @default.
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- W2366888917 date "2005-01-01" @default.
- W2366888917 modified "2023-09-27" @default.
- W2366888917 title "HPLC Determination of Itraconazole and Its Metabolite Hydroxyitraconazole in Human Plasma" @default.
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