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- W2366893233 abstract "Objective:To elucidate the epidemiology of cytomegalovirus (CMV) and Epstein Barr virus (EBV) in children with ITP.Method:CMV and EBV infection was detected in 44 children with ITP by PCR method, which was analyzed with the clinic and laboratory characteristics of these children.Result:Specific viral DNA indicating a current or recent viral infection was detected in 27 patients ( 61.4 %) for CMV and 22 (50%) for EBV by PCR method, respectively. Children with chronic ITP ( 71.9 %) had significantly higher CMV infection compared with acute ITP ( 33.3 %) (χ 2= 5.47 ,P 0.05 ), though there was no significant difference in EBV infection between acute and chronic ITP groups. The clinical manifestations and laboratory data were analyzed in patients with and without virus infection. Children with ITP and associated CMV infection are characterized by a higher positivity of antiplatelet antibodies as well as a lower platelet and megakaryocyte count than patients without CMV infection. Moreover, affected children often showed severe hemorrhaging and poor response to steroids. Thus, infection with CMV should be considered in cases of severe, treatment resistant ITP. However, EBV associated ITP usually manifest as benigh acute onset, mild to moderate thrombocytopenia, normal or increased number of megakaryocyte in the bone marrow and fewer bleeding complications. Anti GPIIb/IIa antibody showed a remarkable increase in EBV positive patients (χ 2= 4.96 ,P 0.05 ) compared to non EBV patients.Conclusion:CMV and EBV should be considered as possible etiologic agents in some children with ITP. Probing into the pathogenesis and clinical features of different virus associated ITP could provide theoretical basis for treatment and prognostic information." @default.
- W2366893233 created "2016-06-24" @default.
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- W2366893233 date "2002-01-01" @default.
- W2366893233 modified "2023-09-25" @default.
- W2366893233 title "CMV and EBV infection in children with ITP" @default.
- W2366893233 hasPublicationYear "2002" @default.
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