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- W2366898466 abstract "Objective To investigate the protective effect of astragalus polysaccharide(APS) on lipopolysaccharide(LPS)-induced cardiac myocytes hypertrophy of rats and its mechanism.Methods Cardiac myocytes of 1—2 d neonatal SD rats were cultured 48 h in vitro,and divided into control,model(LPS 1 mg/L) group,APS low-,middle-,and high-(1,10,and 100 mg/L) groups.The cardiomyocyte volume was assayed by computer photograph analysis;atrial natriuretic peptide(ANP) mRNA expression was measured by RT-PCR;and tumor necrosis factor-α(TNF-α) level was determined by ELISA.The transient peak change of intracellular calcium concentration([Ca2+]i) was measured by using Fluo-3/Am fluorescent dye load cell under laser confocal microscope.Results Compared with control group,LPS 1 mg/L could make the volume of myocardial cells,ANP mRNA expression,the release of TNF-α protein,and [Ca2+]itransient peak increase significantly(P0.01).Compared with the LPS model group,APS pre-administrated at the concentrations of 1,10,and 100 mg/L could inhibit myocardial cell volume increase,while cells of TNF-α were significantly reduced,ANP mRNA expression decreased in varying degrees(P0.05).APS 10 and 100 mg/L groups could be restored to normal levels of the control group(P 0.05) and APS 10 mg/L could antagonize transient changes in amplitude increase of [Ca2+]i in normal cardiac myocytes(P0.01).Conclusion APS does have a good protection on cultured cardiac myocytes hypertrophy and its mechanism may be related to the inhibition of [Ca2+]i." @default.
- W2366898466 created "2016-06-24" @default.
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- W2366898466 date "2012-01-01" @default.
- W2366898466 modified "2023-09-28" @default.
- W2366898466 title "Protection of astragalus polysaccharide on lipopolysaccharide-induced cardiac myocytes hypertrophy of rats" @default.
- W2366898466 hasPublicationYear "2012" @default.
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