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- W2366903962 abstract "Objective: To study the effects and mechanisms of sodium ferulate(SF) on the proliferation of cardiac fibroblasts(CFS) induced by AngⅡ. Methods: Cultured cardiac fibroblasts were respectively treated for 24 hours with 10 -7mmol/L angiotensinⅡ, 0.04 mg/ml SF +angiotensinⅡ, 0.08 mg/ml SF +angiotensinⅡand 0.16 mg/ml SF +angiotensinⅡ. CFs prolifertion was measured by thiazolyl blue(MTT) assay.Cell cyclin distribution was determined with flow cytometry. The expression of TGF-β_1 was detected by immunofluorescence staining. Results: MTT-OD value of AngⅡ Group was significantly higher than that of the control group(P0.01).SF (0.04-0.16 mg/ml) decreased MTT-OD value stimulated by angiotensin Ⅱthrough a dose dependent way (P0.01) . ②In AngⅡ group, the percentage of CFs in S stage was significantly higher than in control group and the percentage of CFs in of G_0/G_1 stage was significantly lower than in control group (P0.01). In AngⅡ +SF(0.04 mg/ml,0.08mg/ml,0.16 mg/ml) groups, the percentage of CFs in S stage was significantly lower than in AngⅡ group and the percentage of CFs in G_0/G_1 stage was significantly higher than in control group.TGF-β_1 protein express of AngⅡ group was significantly higher than that of control group (P0.01) ; TGF-β_1 protein express of AngⅡ+SF significantly lower than that of AngⅡgroup(P0.01). Conclusion: SF inhibits effectively the prolifertion of cultured rat CFs induced by angiotensinⅡthrough a dose dependent way,which is related to the decreasing of TGF-β_ 1 expression." @default.
- W2366903962 created "2016-06-24" @default.
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- W2366903962 date "2006-01-01" @default.
- W2366903962 modified "2023-09-25" @default.
- W2366903962 title "Effects of Sodiumferulate on the Proliferation of Cardiac Fibroblasts" @default.
- W2366903962 hasPublicationYear "2006" @default.
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