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- W2366919139 abstract "Induction effects of the in vivo derivatives of sulfur dioxide (SO_2),i.e.(bi)sulfite on chromosomal aberration (CA) in Chinese hamster fibroblast cell line (CHL cells) were investigated. Results show that the derivatives of SO_2 both in presence and unpresence of S_9 mixture may increase the frequencies of CA in CHL cells in dose-dependent manner. It implies that SO_2,which needs not to be metabolited in vivo,is a direct clastogenetic and genotoxic agent Results also show that SO_2 at low concentrations induces only chromatid-type CA, at high concentration induces both chromatid-type and chromosome-type CA, and also indicate that the lowest concentration of the chemical to cause the cytogenetic damage is lower with the bine the cells exposed to (hi)sulfite. It implies that long-exposing to SO_2 pollutant at low concentration in air environment may be a potential risk to induce damage of cytogenetic material in vivo for human beings." @default.
- W2366919139 created "2016-06-24" @default.
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- W2366919139 date "2000-01-01" @default.
- W2366919139 modified "2023-09-25" @default.
- W2366919139 title "Induced effects of the in vivo derivatives of sulfur dioxide on chromosomal aberration in CHL cells." @default.
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