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- W2366936404 abstract "Objective To explore the changes in expression of cytochrome C protein of hippocampal neurons and the contents of caspase mRNA after thrombotic cerebral ischemia,we will provide a molecular mechanism of mitochondrial stress resulting in the hippocampal neurons secondary injury.Methods The expression of cytochrome C was observed in ischemic lateral hippocampi at different times by immunochemistry.Also,the hippocampus was removed,then mitochondria and cytoplasmic fragment were divided by low temperature centrifugation and the distribution of cytochrome C was assessed through western blot.We used real time fluorescence polymerase chain reaction to evaluate the contents of caspase-3 and caspase-9 mRNA.Results Cytochrome C was released from mitochondria into the cytosol at 24h.The contents of caspase-3 and caspase-9 mRNA increased.There was a positive correlation between caspase-3 and caspase-9.Conclusion After photochemical inducing cerebral ischemia in tree shrews,hipppocampal neuronal mitochondrias begin to stress and proapoptotic protein cytochrome C released from mitochondria into cytoplasm,which trigger caspase cascade reaction.This is one of the pathophysiological mechanism about hippocampal neuronal secondary injury after cerebral ischemia." @default.
- W2366936404 created "2016-06-24" @default.
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- W2366936404 date "2007-01-01" @default.
- W2366936404 modified "2023-09-24" @default.
- W2366936404 title "The mechanisms of hippocampal mitochondrial stress and neuronal injury after thrombotic cerebral ischemia in Tree Shrews" @default.
- W2366936404 hasPublicationYear "2007" @default.
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