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- W2366943750 abstract "Objective:To investigate the expression of myocardium connexin43 and connexin45 in fetal rat of intrahepatic cholestasis of pregnancy(ICP).Methods:The animal model of ICP was induced by 17-α-Ethinylestradiol and Progesterone.Ultrastructural changes of intercalated disk of fetal rat myocardial cells(FRMCs) were observed by electromicroscope.Expression of connexin43 and connexin45 of FRMCs were observed by immunohistochemistry,RT-PCR and Western Blot.Results:(1)It showed vague ultrastructure in some parts of intercalated disk and disappeared gap junctions of FRMCs in Group ICP.(2)Expression of connexin43 by immunohistochemistry,RT-PCR and Western Blot was downregulated significantly in FRMCs of Group ICP when compared to control,P0.01.(3)No obvious differences were found about the expression of connexin45 by immunohistochemistry,RT-PCR and Western Blot in FRMCs between Group ICP and control,P0.05.Conclusion:It demonstrated that ultrastructural changes of gap junction,downregulation of connexin43 and inhibition of gap junction intercellular communication in FRMCs might contribute to fetal rat arrhythmia and sudden death in ICP." @default.
- W2366943750 created "2016-06-24" @default.
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- W2366943750 date "2009-01-01" @default.
- W2366943750 modified "2023-09-23" @default.
- W2366943750 title "Expression of myocardium connexin-43 and connexin45 and sudden death in fetal rat of intrahepatic cholestasis of pregnancy" @default.
- W2366943750 hasPublicationYear "2009" @default.
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