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- W2366969160 abstract "Objective: To investigate whether interleukin 18 (IL 18), a novel pro inflammatory cytokine, is expressed and localized in the thyrocytes of Hashimoto's thyroiditis (HT). Methods: Thyroid tissues were obtained from six patients with HT and six patients with subacute thyroiditis (ST) by using automatic biopsy device which was employed for pathological diagnosis. Control thyroid tissues were from six patients laryngectomized due to laryngocarcinoma. Immunohistochemical staining was used to detect IL 18 expression. Results: IL 18 expression was barely detectable in normal thyroid tissues. However, IL 18 expression was more abundant in the thyroid tissues of HT group than in those of ST group. The expression was mainly localized in thyroid follicular cells from HT patients and in the mononuclear macrophages within sarcoid from ST patients. Conclusion: Our preliminary data have demonstrated for the first time that IL 18 can be expressed in the thyrocytes of HT. IL 18 may play an important role in the pathogenesis of HT." @default.
- W2366969160 created "2016-06-24" @default.
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- W2366969160 date "2000-01-01" @default.
- W2366969160 modified "2023-09-25" @default.
- W2366969160 title "The first report of interleukin 18 expression in the thyrocytes of Hashimoto's thyroiditis" @default.
- W2366969160 hasPublicationYear "2000" @default.
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