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- W2366970488 abstract "AIM:To prepare 5-fluorouracil albumin microspheres coated by N-galactosylated chitosan derivative for liver targeting. METHOD:First,fluorouracil bovine serum albumin microspheres were prepared by emulsion-crosslinking stabilization technique,and were optimized by the uniform design and single factor optimization,then the microspheres were coated chitosan derivative,orthogonal experiment design was used to get the optimum coated condition. RESULT:The preparation procedure after optimization is:5-Fu 10.0 mg/ml,w/o=1/20,glutaraldehyde 1.0 ml,cross-linking time 4 h,the concentrations of derivative and acetic acid both are 2% and coating time is 10 min. CONCLUSION:The preparation procedure is good and simple;the experiment design is economical and effective." @default.
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- W2366970488 date "2004-01-01" @default.
- W2366970488 modified "2023-09-25" @default.
- W2366970488 title "Preparation of 5-Fluorouracil Albumin Microsphere Coated by N-Galactosylated Chitosan Derivative" @default.
- W2366970488 hasPublicationYear "2004" @default.
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