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- W2366972814 abstract "Objective To establish the model of ob/ob mouse orthotopic liver transplantion (OLT) and investigate the experience.Methods The techniques of a non-arterialized murine transplant model were applied.C57BL6 ob/ob mice aged 5-7 weeks (25-35) g and lean controls served as liver donors and recipients respectively.OLT was performed using a two-cuff technique at the infrahepatic cava and portal vein.The suprahepatic cava was anastomosed end to end and the bile duct was stented.The hepatic artery was not reconstructed.Results Lean-to-lean OLT was performed with 70% (n= 10) long-term survival.ob/ob-to-age-matched lean recipients had 0% (n= 10) survival due to size discrepancy.ob/ob livers were transplanted to size-matched lean recipients (3 months old) with short-term survival of 30% (n= 10).These mice survived the operation,awakened,but expired within 24 h.Serum transaminases revealed a significantly higher injury profile in the recipients of the steatotic livers,and histology showed massive centrilobular coagulative necrosis with hemorrhage,the overall picture being that of primary nonfunction.Conclusion This novel use of ob/ob mouse for OLT provides us with a model for steatotic transplantation with PNF as the endpoint,and may help better understand the response of the steatotic liver to the insult of transplantation." @default.
- W2366972814 created "2016-06-24" @default.
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- W2366972814 date "2004-01-01" @default.
- W2366972814 modified "2023-09-27" @default.
- W2366972814 title "Establishment of steatotic liver transplantation in the mouse" @default.
- W2366972814 hasPublicationYear "2004" @default.
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