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- W2366979454 abstract "Objective To investigate the effects of ketamine on neuronal injury following global ischemia and reperfusion in rats.Methods Global ischemia was induced by 15 minutes using the method described by Pulsinelli with modification.All rats were divided into 4 groups:sham-operated group;ischemia-reperfusion group;postischemia ketamine-treated group;preischemia ketamine-treated group.Y-type maze was used to detect the behavior change at day 6 and 7 postischemia.Histopathology test were carried out at day 7 postischemia.Results The learning and memory function of the rats were reduced after global ischemia and reperfusion.A large number of neurons lost in the CA1 region of hippocamus.More neurons survived in postischemia ketamine-treated group and preischemia ketamine-treated group.The learning and memory function were improved.Conclusion Ketamine provided neuroprotective effects." @default.
- W2366979454 created "2016-06-24" @default.
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- W2366979454 date "2003-01-01" @default.
- W2366979454 modified "2023-09-24" @default.
- W2366979454 title "The neuroprotective effects of ketamine on neuronal injury following global ischemia and reperfusion in rats" @default.
- W2366979454 hasPublicationYear "2003" @default.
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